Fig. 10. A new folding pattern for yeast VDAC in a membrane and the proposed motion of regions of the protein upon channel closure. In the upper panel b -strand #7 from the N-terminus (Fig. 8) was moved so as to lie between b -strand #3 and 4. In the lower panel, regions proposed to move out of the channel in one of the two gating processes (positive potential below the membrane).