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Representative publications

Anishkin A, Chiang CS, Sukharev S.  
Gain-of-function Mutations Reveal Expanded Intermediate States and a Sequential Action of Two Gates in MscL.
J Gen Physiol. 2005, 125(2):155-170.

Akitake B, Anishkin A, Sukharev S.  
The "Dashpot" Mechanism of Stretch-dependent Gating in MscS.
J Gen Physiol. 2005, 125(2):143-154.

Anishkin A, Sukharev S.
Water dynamics and dewetting transitions in the small mechanosensitive channel MscS.
Biophys J. 2004, 86(5):2883-2895.

Anishkin A, Gendel V, Sharifi NA, Chiang CS, Shirinian L, Guy HR, Sukharev S.
On the Conformation of the COOH-terminal Domain of the Large Mechanosensitive Channel MscL.
J Gen Physiol. 2003 Mar;121(3):227-44.

Betanzos M, Chiang CS, Guy HR, Sukharev S.
A large iris-like expansion of a mechanosensitive channel protein induced by membrane tension. 
Nat Struct Biol. 2002 Sep;9(9):704-10.

Sukharev S, Betanzos M, Chiang CS, Guy HR.    
The gating mechanism of the large mechanosensitive channel MscL.
Nature. 2001 Feb 8;409(6821):720-4.

Sukharev SI, Sigurdson WJ, Kung C, Sachs F.   
Energetic and spatial parameters for gating of the bacterial large conductance mechanosensitive channel, MscL.
J Gen Physiol. 1999 Apr;113(4):525-40.

Sukharev SI, Blount P, Martinac B, Blattner FR, Kung C.    
A large-conductance mechanosensitive channel in E. coli encoded by mscL alone.
Nature. 1994 Mar 17;368(6468):265-8.

Sukharev SI, Blount P, Martinac B, Kung C.    
Mechanosensitive channels of Escherichia coli: the MscL gene, protein, and activities.
Annu Rev Physiol. 1997;59:633-57. Review.

 

Full list

Sukharev S, Anishkin A. 
Explicit channel conductance: can it be computed? 
Biophys J. 2005, Mar 11; [Epub ahead of print] Review. 

Anishkin A, Chiang CS, Sukharev S.  
Gain-of-function Mutations Reveal Expanded Intermediate States and a Sequential Action of Two Gates in MscL.
J Gen Physiol. 2005, 125(2):155-170.

Akitake B, Anishkin A, Sukharev S.  
The "Dashpot" Mechanism of Stretch-dependent Gating in MscS.
J Gen Physiol. 2005, 125(2):143-154.

Sukharev S, Anishkin A.
Mechanosensitive channels: what can we learn from 'simple' model systems?
Trends Neurosci. 2004, 27(6):345-351. Review. 

Anishkin A, Sukharev S.
Water dynamics and dewetting transitions in the small mechanosensitive channel MscS.
Biophys J. 2004, 86(5):2883-2895.

Chiang CS, Anishkin A, Sukharev S.
Gating of the large mechanosensitive channel in situ: estimation of the spatial scale of the transition from channel population responses.
Biophys J. 2004, 86(5):2846-2861.

Sukharev S, Corey DP. 
Mechanosensitive channels: multiplicity of families and gating paradigms.
Sci STKE. ;2004(219):re4. Review. 

Anishkin A, Gendel V, Sharifi NA, Chiang CS, Shirinian L, Guy HR, Sukharev S.
On the Conformation of the COOH-terminal Domain of the Large Mechanosensitive Channel MscL.
J Gen Physiol. 2003 Mar;121(3):227-44.

Betanzos M, Chiang CS, Guy HR, Sukharev S.
A large iris-like expansion of a mechanosensitive channel protein induced by membrane tension. 
Nat Struct Biol. 2002;9(9):704-10.

Sukharev S. 
Purification of the small mechanosensitive channel of Escherichia coli (MscS): the subunit structure, conduction, and gating characteristics in liposomes.
Biophys J. 2002 Jul;83(1):290-8.

Sukharev S, Durell SR, Guy HR.   
Structural models of the MscL gating mechanism.   
Biophys J. 2001 Aug;81(2):917-36.

Ermakov YA, Averbakh AZ, Yusipovich AI, Sukharev S.   
Dipole potentials indicate restructuring of the membrane interface induced by gadolinium and beryllium ions.
Biophys J. 2001 Apr;80(4):1851-62.

Sukharev S, Betanzos M, Chiang CS, Guy HR.   
The gating mechanism of the large mechanosensitive channel MscL.
Nature. 2001 Feb 8;409(6821):720-4.

Sukharev SI, Schroeder MJ, McCaslin DR.   
Stoichiometry of the large conductance bacterial mechanosensitive channel of E. coli. A biochemical study.
J Membr Biol. 1999 Oct 1;171(3):183-93.

Sukharev SI, Sigurdson WJ, Kung C, Sachs F.   
Energetic and spatial parameters for gating of the bacterial large conductance mechanosensitive channel, MscL.
J Gen Physiol. 1999 Apr;113(4):525-40.

Sukharev S.   
Mechanosensitive channels in bacteria as membrane tension reporters.
FASEB J. 1999;13 Suppl:S55-61. Review.

Blount P, Sukharev SI, Moe PC, Martinac B, Kung C.   
Mechanosensitive channels of bacteria.
Methods Enzymol. 1999;294:458-82. Review. No abstract available.

Arkin IT, Sukharev SI, Blount P, Kung C, Brunger AT.   
Helicity, membrane incorporation, orientation and thermal stability of the large conductance mechanosensitive ion channel from E. coli.
Biochim Biophys Acta. 1998 Feb 2;1369(1):131-40.

Ermakov YuA, Averbakh AZ, Arbuzova AB, Sukharev SI.   
Lipid and cell membranes in the presence of gadolinium and other ions with high affinity to lipids. 2. A dipole component of the boundary potential on membranes with different surface charge.
Membr Cell Biol. 1998;12(3):411-26.

Blount P, Sukharev S, Kung C.   
A mechanosensitive channel protein and its gene in E. coli.
Gravit Space Biol Bull. 1997 Jun;10(2):43-7. Review.

Blount P, Sukharev SI, Moe P, Kung C   
Mechanosensitive channels of E. coli: a genetic and molecular dissection.
Biol Bull. 1997 Feb;192(1):126-7. No abstract available.

Sukharev SI, Blount P, Martinac B, Kung C.   
Mechanosensitive channels of Escherichia coli: the MscL gene, protein, and activities.
Annu Rev Physiol. 1997;59:633-57. Review.

Ermakov YuA, Averbakh AZ, Sukharev SI.   
Lipid and cell membranes in the presence of gadolinium and other ions with high affinity to lipids. 1. Dipole and diffuse components of the boundary potential.
Membr Cell Biol. 1997;11(4):539-54.

Blount P, Sukharev SI, Schroeder MJ, Nagle SK, Kung C.   
Single residue substitutions that change the gating properties of a mechanosensitive channel in Escherichia coli.
Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11652-7.

Blount P, Sukharev SI, Moe PC, Schroeder MJ, Guy HR, Kung C.   
Membrane topology and multimeric structure of a mechanosensitive channel protein of Escherichia coli.
EMBO J. 1996 Sep 16;15(18):4798-805.

Blount P, Sukharev SI, Moe PC, Nagle SK, Kung C.   
Towards an understanding of the structural and functional properties of MscL, a mechanosensitive channel in bacteria.
Biol Cell. 1996;87(1-2):1-8. Review.

Sukharev SI, Blount P, Martinac B, Guy HR, Kung C.   
MscL: a mechanosensitive channel in Escherichia coli.
Soc Gen Physiol Ser. 1996;51:133-41. Review. No abstract available.

Sukharev SI, Blount P, Martinac B, Blattner FR, Kung C.   
A large-conductance mechanosensitive channel in E. coli encoded by mscL alone.
Nature. 1994 Mar 17;368(6468):265-8.

Saimi Y, Martinac B, Preston RR, Zhou XL, Sukharev S, Blount P, Kung C.   
Ion channels of microbes.
Soc Gen Physiol Ser. 1994;49:179-95. Review. No abstract available.

Sukharev SI, Martinac B, Arshavsky VY, Kung C.   
Two types of mechanosensitive channels in the Escherichia coli cell envelope: solubilization and functional reconstitution.
Biophys J. 1993 Jul;65(1):177-83.