Apoptosis: the roles of VDAC and Ceramide:

Vander Heiden, M.G., Chandel, N.S., Li, X.X., Schumacker, P.T., Colombini, M., and Thompson, C.B. 2000. Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival.  Proceedings of the National Academy of Sciences U.S.A., 97: 4666-4671.

Siskind, L.J., and Colombini, M. 2000. The lipids C2- and C16-ceramide form large stable channels: implications for apoptosis.  Journal of Biological Chemistry, 275: 38640-38644.   Full Text

Vander Heiden,M.G., Li, X.X. , Gottleib, E. , Hill, R.B., Thompson, C.B., and Colombini, M. 2001. Bcl-xL Promotes the Open Configuration of VDAC and Metabolite Passage through the Mitochondrial Outer Membrane.  Journal of Biological Chemistry,  276: 19414-19419.

Siskind, L.J., Kolesnick, R.N. and Colombini, M. 2002. Ceramide channels increase the permeability of the mitochondrial outer membrane to small proteins. Journal of Biological Chemistry, 277: 26796-26803.  Full Text

Siskind, L. J., Davoody, A., Lewin, N., Marshall, S. and Colombini, M. 2003. Enlargement and Contracture of C2-Ceramide Channels.  Biophysical Journal,  85:1560-1575.  Full Text

Rostovtseva, T.K., Antonsson, B., Suzuki, M., Youle, R.J., Colombini, M., Bezrukov, S.M.  2004. Bid but not Bax regulates VDAC channels.  Journal of Biological Chemistry, 279:13575-13583.

Siskind, L. J., Fluss, S., Bui, M., and Colombini, M. 2005. Sphingosine forms channels in membranes that differ greatly from those formed by ceramide.  Journal of Bioenergetics and Biomembranes.  37: 227-236.  Full Text

Rostovtseva, T.K., Tan, W., and Colombini, M. 2005.
On the role of VDAC in apoptosis: fact and fiction.   Journal of Bioenergetics and Biomembranes.  37: 129-142.


Siskind, Leah J.  2005. Mitochondrial Ceramide and the Induction of Apoptosis. Journal of Bioenergetics and Biomembranes.  37: 143-153. 

 Full Text

Stiban, J., Fistere Jr., D., and Colombini, M. 2006. Dihydroceramide hinders ceramide channel formation: implications on apoptosis.  Apoptosis  11:773-80.  

Full Text

Elrick, M.J.,  Fluss, S., and  Colombini, M. 2006.  Sphingosine, a product of ceramide hydrolysis by ceramidase, influences the formation of ceramide channels.  Biophysics Journal, 91: 1749-1756.  

Full Text

Siskind, L. J., Kolesnick, R.N. and Colombini, M. 2006.  Ceramide forms channels in mitochondrial outer membranes at physiologically relevant concentrations.   Mitochondrion 6:118-25.  

 Full Text

 Anishkin, A., Sukharev, S., and Colombini, M. 2006.
Searching for the molecular arrangement of transmembrane ceramide channels.  Biophysical Journal, 90:2414-2426.  

Full Text

 Stiban J., Caputo L. and Colombini M. 2008.  Ceramide synthesis in the endoplasmic reticulum can permeabilize mitochondria to pro-apoptotic proteins. Journal of Lipid Research, 49: 625-634.

Full Text


Siskind L.J., Feinstein, L., Yu, T., Davis, J.S., Jones, D., Choi, J., Zuckerman, J.E., Tan, W., Hill, R.B., Hardwick, J.M. and Colombini, M. 2008. Anti-apoptotic Bcl-2 family proteins disassemble ceramide channels. Journal of Biological Chemistry 283: 6622-6630.      Full Text





Return to main page