Fig. 15. Dextran sulfate
(8 kDa) increases the voltage dependence of VDAC. The conductance of VDAC
reconstituted into planar membranes (as in Fig. 1except
that the medium consisted of 1 M LiCl, 5 mM CaCl2)
declines with increasing voltage in the absence (x) and in the presence
of dextran sulfate (6.25 m M ( ); 25
mM (+)). Reproduced with permission from Mangan
and Colombini (1987).