Fig. 11. Effect of glutamate
(E) to lysine (K) substitutions at positions 145 (E145K) and 152 (E152K)
on the voltage dependence of yeast VDAC. The steepness of
the voltage dependence was measured in the presence
of 5.75 x 10-2 mg/ml dextran sulfate (500kDa), a value that magnifies the
steepness of the voltage
dependence by a factor of 10 (see also Fig.
15). The two bars indicate the voltage dependence of each of the two
gating processes. This is a replotting of the data of
Zizi et al., 1995.