Assistant Professor
Ph.D. - University of Iowa,
1991
Center for Advanced Research
in Biotechnology
9600 Gudelsky Drive
Rockville, MD 20850
Telephone: (301)-738-6208
E-mail: arlin@carb.nist.gov
Research Interests: Computational evolutionary biology
Our research is directed toward
improving our understanding of the origin and evolution of
macromolecular sequence and structure. This
research utilizes computational and analytical modelling of
evolutionary processes, as well as quantitative analyses of
sequence and structure data from genes, proteins, and
genomes. Ongoing and planned projects include
testing hypotheses regarding the evolutionary history of
introns and intron-containing genes; developing
bioinformatics tools to aid in molecular evolution research;
developing a general theoretical framework for
understanding the role of mutation biases in evolution; and
developing models that address the evolution of novelty at
the molecular level. Recent work includes
computer simulations of a neutral model for the
stabilization and persistence of duplicate gene loci; and
computer simulations and analytical modelling of a
rough-fitness-landscape model that reveals how mutation
biases are expected to influence the course of evolution
under selection. For more information, please visit our web
site at http://www.molevol.org/camel.
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