David
M. MosserDavid
M. Mosser Research Interests: Innate Immunity to Microbial Pathogens.
Mosser Lab
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Macrophages and dendritic cells occupy a unique niche in the immune system. These cells not only participate in host defense to infectious microorganisms, but they also mediate potentially deleterious host inflammatory responses. A variety of experimental approaches in Immunology and Cell Biology have begun to reveal the molecular mechanisms by which these cell types can mediate these two divergent processes.
Studies on host defense to infectious diseases focus on: I) the cell and molecular biology of macrophage infection by intracellular pathogens. II) the molecules produced by macrophages that mediate the killing of intracellular pathogens. III) the development of recombinant parasites that may be used as a vaccine against virulent Leishmania spp.
Studies relating to the host inflammatory response focus on: I) the regulation of cytokine gene expression in macrophages and dendritic cells. II) receptor-mediated modulation of cytokine production. III) the development of novel anti-inflammatory therapies to treat autoimmune diseases.
Sutterwala, F.S. and Mosser, D.M. 1999. The taming of IL-12: suppressing the production of proinflammatory cytokines. J. Leukocyte Biology 65:543-551.
D.M. Mosser and C.L. Karp 1999. Receptor-mediated subversion of macrophage cytokine production by intracellular pathogens. Current Opinion in Immunology 11:406-411.
Brittingham, A., Chen, G., McGwire, B.S., Chang, K.P. and Mosser, D.M. 1999. The interaction of Leishmania gp63 with cellular receptors for fibronectin. Infection and Immunity 67:4477-84.
Mentink Kane, M. and Mosser, D.M. 2000. Leishmania parasites and their ploys to disrupt macrophage activation. Curr. Opinion. Hematol. 7:26-31.
Darrah, P.A., Hondalus, M.K., Chen, Q., Ischiropoulos, H. and Mosser, D.M. 2000. Cooperation between Reactive Oxygen and Nitrogen Intermediates in the Killing of Rhodococcus equi by Activated Macrophages. Infection and Immunity 68:3587-3593.
Mentink Kane, M. and Mosser, D.M. 2001. The role of IL-10 in promoting disease progression in Leishmaniasis. J. Immunology 166:1141-1147.
Gerber, J.G. and Mosser, D.M. 2001. Stimulatory and inhibitory signals originating from the macrophage Fcγ Receptors. Microbes and Infection in press.
Cappiello, M.G., Sutterwala, F.S., Trinchieri, G., Mosser, D.M. and Ma, X. 2001. Suppression of IL-12 transcription following Fcγ receptor ligation. Journal of Immunology 166:4498-4506.
Chen, G., Darrah, P.A., and Mosser, D.M. 2001. Vaccination against the intracellular pathogen, Leishmania spp by directing CD40 ligand to macrophages. Infection and Immunity 69:3255-63.
Bagenstose, L.M., Mentink-Kane, M.M., Brittingham, A.B., Mosser, D.M. and Monestier, M. 2001. Mercury enhances susceptibility to murine leishmaniasis. Parasite Immunol 23:633-640.
Gerber, J.S. and Mosser, D.M. 2001. Reversing lipopolysaccharide toxicity by ligating the macrophage Fcγ receptors. J. Immunology 166:6861-6868.
Loan-Facsinay, A., de Kimpe, S.J., Hellwig, S.M.M., van Lent, P.L., Hofhius, F.M., van Ojik, H.H. Gerber, J., Mosser, D.M., van de Winkel, J.G.J., and Verbeek, J.S. 2002. FcgR1 (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection. Immunity. 16:391-402.
Anderson, C.A. and Mosser, D.M. 2002. Cutting Edge: Biasing immune responses by directing antigen to macrophage Fcg receptors. J. Immunology. 168:3697-3701.
Anderson, C.A. and Mosser, D.M. 2002. A novel macrophage phenotype: the Type
II macrophage. J. Leukocyte Biology. In press.
Maria Chiara Monaco, Ph.D., Research Asst. Professor
Mark Lucas, Ph.D., Research Asst. Professor
Illya Tietzel, Ph.D., Postdoctoral fellow
Kristen Roberts, Faculty Research associate
Suzanne Miles, Graduate student
Sean Conrad, Graduate student
Nandhakumar Kanaqarajan, Graduate student
Annie Field, Graduate student
Eric Hansen, Undergraduate student