Syllabus

Instructor: Dr. Philip deShong

This course will describe the processes employed for development of new pharmaceuticals, focusing on the human use market. After a general introduction to the methodology for drug development, the course will focus on

(1) the current pharmaceuticals on the market for a specific disease state,

(2) the mode of action of these drugs,

(3) the limitations of the specific approach (ie. side effects, bioavailability), and

(4) promising alternative approaches.

Unit One: General Strategies for Drug Development

• Biology of the Disease
• Chemistry and "Lead" Identification
• Development of Lead Structures
• Clinical Trials

Unit Two: Antibiotics

• Sulfa Drugs
• Penicillins
• Vancomycin

Unit Three: Blood Pressure Drugs

Unit Four: Cholesterol Lowering Agents

Unit Five: Cancer Chemotherapy Agents

• Mustards
• Adriamycin
• Taxol

Unit Six: Modern Strategies

• Combinatorial Chemistry
• Biotechnology Approaches
• Genomics and Proteomics