Courses
 |
|
 |
|
 |
|
 |
|
 |
|
 |
|
 |
|
 |
|
 |
|
 |
|
 |
|
LFSC 620
MODERN MOLECULAR GENETICS
LFSC 620: Molecular Biology and Genetics (3 credits) An overview of the discipline of genetics and equip students to work from basic principles to understand and appreciate both classical and modem molecular genetics. Advanced topics will include the increased understanding of the genetic basis/components in prevalent diseases, genetically engineered organisms and foods, the importance of knowing the complete DNA sequence of organisms including humans. Instructor: Dr. Paul Bottino
Textbook: Genetics, The Continuity of Life, Daniel J Fairbanks and W. Ralph Anderson. Brookscole/ Wadsworth 2nd Ed. 2001.
Module 1
DNA Structure and Replication Ch 2
DNA as the Genetic Material
Nucleic Acid Structure
Semi-conservative DNA replication
Module 2
Transription and Translation Ch 3-4
Initiation-Promotors and Enhancers
Elongation
Termination,
RNA Processing
Proteins, Protein Synthesis and the Genetic Code
Translation-Initiation, Elongation, Termination
Module 3
Relationship Between Genes and Phenotypes Ch 5-6
Mutations and Phenotypes
Gene Expression and Phenotypes
Biochemical Genetics-Altered Pathways
Module 4
Regulation of Gene Expression Ch 8
The lac operon
The trp operon
Transcriptional Gene Regulation in Eukaryotes
Module 5
Recombinant DNA and Molecular Analysis Ch 9
Recombinant DNA
Cloning Vectors-small and large inserts
Cloning Strategies
PCR
Electrophoresis
DNA and Protein Blotting
DNA Sequencing
Module 6
Eukaryotic Genome Organization Ch 10
Repetitive DNA and Renaturation Kinetics
Eukaryotic DNA Packaging
Chromosome Structure
Whole Genome Organization
Module 7
Transposable Elements Ch 22
Eukaryotic Transposons-Corn and Drosophila
Prokaryotic Transposons-Insertion Sequences, Composite Elements
Genetic Applications
Module 8
Developmental Genetics Ch 23
Genetic Control of Development in C. elegans
Genetic Control of Development in Drosophila
Flower Development in Arabidopsis thaliana
Module 9
Genes and Cancer Ch 24
Cell Cycle Regulation
Molecular Basis of Cancer
Genes that Influence Cancer
Etiology of Cancer
Module10
. Genes and Immunity Ch 25
A. The Immune Response
B. Antibody Structure
C. Antibody Genes
D. Immune System Malfunction
Module 11
Applicatiions of Genetics-Medicine-Forensics-Agriculture Ch 26-27
The Human Genome Project
Genetic Testing-DNA Fingerprinting
C. Genetic Pharmacology
Human Gene Therapy
Genetic Diversity-Conservation Genetics
Plant Biotechnology-Genetically Modified Crops
Module 12
Legal and Ethical Issues in Genetics Ch 28
Eugenics
Genetic Testing and Screening
Intellectual Property Rights in Genetics
Recombinant DNA and Safety
