BSCI 424 — PATHOGENIC MICROBIOLOGY — Fall 2000

Bordetella Summary


 

Bordetella pertussis

  Extremely small, Gram-negative coccobacilli
(see WebLinked image; B. holmesii WebLinked image)

  Obligate aerobes


  Highly communicable (highly infectious)


  Person-to-person spread via inhalation of infectious aerosols


  Man is only natural host; Obligate parasites of man


  Multiply among cilia of epithelial cells


  Three distinct stages of disease:
  1. catarrhal
  2. paroxysmal
  3. convalescent

  Produce filamentous hemagglutinin and classic A-B exotoxin and other toxins


  Classical A-B exotoxin has three distinct activities:
  1. histamine sensitizing factor
  2. lymphocytosis promoting factor
  3. islet activating protein

  Isolated on modified Bordet-Gengou agar


  Treatment: erythromycin, suction, oxygen


  Inactivated whole bacterial cells and toxoid are prepared in formalin for inclusion in DPT vaccine
 
 

   Return to Pathogen List

 

 

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Designed & Maintained by David M. Rollins
Copyright © 2000, D.M. Rollins and S.W. Joseph
Revised: August 2000
URL: http://life.umd.edu/classroom/bsci424