Retrospective study of outbreak data led to discovery of this organism in the late 1970ís
Commonly present in water sources; grow and multiply intracellularly in protozoa
Facultative Gram-negative intracellular pathogen (see WebLinked image) capable of growing inside human white blood cells (leukocytes including neutrophils and pulmonary macrophages)
Cell-mediated immunity important in protection
Infection via continueing common-source airborne exposure, e.g., air conditioning cooling towers, evaporative condensers, nebulizers, whirlpools, etc.
Human pulmonary infections with two clinical presentations:
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