Virology Graduate Training Program at the University of Maryland

JOURNAL CLUB 

Journal Club Spring 2005

Replication and Translation of RNA Viruses

Meeting time:  3:00 pm- 4:50 pm

Meeting place:  Microbiology Building Rm  2119 

Students who would like credit should sign up for 2 credits  

(Note the first meeting day is the third Friday in the semester and note the last day is a day after the semester ends)

The last three dates will be an exercise in how to review papers for journals.  You will have a chance to compare your review with reviews from professionals

Date

Authors

Paper

 

 

2/11

Daughenbaugh et al

The genome-linked protein VPg of the Norwalk virus binds eIF3, suggesting its role in translation initiation complex recruitment

EMBO J 22, 2852-2959

(2004)

2/18

Otto et al

The pathway of HCV IRES-mediated translation initiation

Cell 119, 269-380  (2004)

2/25

Spahn et al

Cryo-EM visualization of a viral internal ribosome entry site bound to human ribosomes:  The IRES functions as an RNA-based translation factor

Cell 118, 465-475 (2004

3/4

Rao, et al

Crucial role of CA cleavage sites in the cap-snatching mechanism for initiating viral mRNA synthesis

EMBO J. 22, 1188-1198

(2003)

3/11

Lin and White

A complex network of RNA-RNA interactions controls subgenomic mRNA transcription in a tombusvirus

EMBO J. 23 3385-3374 (2004)

3/18

Guogas et al

Cofolding organizes Alfalfa mosaic virus RNA and coat protein for replication

Science 306, 2108-2111 (2004)

4/1

Ke et al

A conformational switch controls hepatitis delta virus ribozyme catalysis

Nature 429, 201-205 (2004)

4/9

Grdzelishvili et al

Mutual interference between genomic RNA replication and subgenomic mRNA transcription in Brome mosaic virus

J. of Virology 79, 1438-1451

(2004)

4/16

Gallei et al

RNA recombination in vivo in the absence of viral replication

J. of Virology 78, 6271-6281 (2004)

4/23

Ranjith-Kumar et al

De novo initiation pocket mutations have multiple effects on Hepatitis C virus RNA-dependent RNA polymerase activities

J. of Virology 78, 12207-12217 (2004)

4/30

  Paper to be reviewed by the class:  Occurence of a DNA sequence of a non-retroRNA virus in a host plant genome and its expression:  evidence for recombination between viral and host RNAs

 

 

5/6

 

Paper to be reviewed by the class:  Mutational Analysis of the Red clover necrotic mosaic virus RNA-2 Trans-Activator (not original choice but other not available on PDF)

 

 

5/13

 

TBA