David M. Mosser

Professor

Research Interests: Innate and Adaptive Immunity to Microbial Pathogens.

Mosser Lab Homepage

The Maryland Pathogen Research Institute (MPRI)

Macrophages and dendritic cells occupy a unique niche in the immune system. These cells not only participate in host defense to infectious microorganisms, but they also mediate potentially deleterious host inflammatory responses. A variety of experimental approaches in Immunology and Cell Biology have begun to reveal the molecular mechanisms by which these cell types can mediate these two divergent processes.

Studies on host defense to infectious diseases focus on: I) the cell and molecular biology of macrophage infection by intracellular pathogens. II) the molecules produced by macrophages that mediate the killing of intracellular pathogens. III) the development of transgenic parasites expressing human immune genes that may be used as vaccines against virulent Leishmania spp.

Studies relating to the host inflammatory response focus on: I) the regulation of cytokine gene expression in macrophages and dendritic cells. II) receptor-mediated modulation of cytokine production. III) the development of novel anti-inflammatory therapies to treat autoimmune diseases.

Recent Publications

F.S., Noel, G.J., Salgame, P.S. and Mosser, D.M.. 1998. Reversal of proinflammatory responses by ligating the macrophage FcγRI. J. Experimental Medicine 188:217-222.

Sutterwala, F.S. and Mosser, D.M.. 1999. The taming of IL-12: suppressing the production of proinflammatory cytokines. J. Leukocyte Biology 65:543-551.

D.M. Mosser and C.L. Karp 1999. Receptor-mediated subversion of macrophage cytokine production by intracellular pathogens. Current Opinion in Immunology 11:406-411.

Brittingham, A., Chen, G., McGwire, B.S., Chang, K.P. and Mosser, D.M.. 1999. The interaction of Leishmania gp63 with cellular receptors for fibronectin. Infection and Immunity 67:4477-84.

Mentink Kane, M. and Mosser, D.M.. 2000. Leishmania parasites and their ploys to disrupt macrophage activation. Curr. Opinion. Hematol. 7:26-31.

Darrah, P.A., Hondalus, M.K., Chen, Q., Ischiropoulos, H. and Mosser, D.M.. 2000. Cooperation between Reactive Oxygen and Nitrogen Intermediates in the Killing of Rhodococcus equi by Activated Macrophages. Infection and Immunity 68:3587-3593.

Mentink Kane, M. and Mosser, D.M.. 2001. The role of IL-10 in promoting disease progression in Leishmaniasis. J. Immunology 166:1141-1147.

Gerber, J.G. and Mosser, D.M.. 2001. Stimulatory and inhibitory signals originating from the macrophage Fcγ Receptors. Microbes and Infection 3:131-139.

Cappiello, M.G., Sutterwala, F.S., Trinchieri, G., Mosser, D.M.. and Ma, X. 2001. Suppression of IL-12 transcription following Fcγ receptor ligation. Journal of Immunology 166:4498-4506.

Chen, G., Darrah, P.A., and Mosser, D.M.. 2001. Vaccination against the intracellular pathogen, Leishmania spp by directing CD40 ligand to macrophages. Infection and Immunity 69:3255-63.

Bagenstose, L.M., Mentink-Kane, M.M., Brittingham, A.B., Mosser, D.M.. and Monestier, M. 2001. Mercury enhances susceptibility to murine leishmaniasis. Parasite Immunol 23:633-640.

Gerber, J.S. and Mosser, D.M.. 2001. Reversing lipopolysaccharide toxicity by ligating the macrophage Fcγ receptors. J. Immunology 166:6861-6868.

Loan-Facsinay, A., de Kimpe, S.J., Hellwig, S.M.M., van Lent, P.L., Hofhius, F.M., van Ojik, H.H. Gerber, J., Mosser, D.M.., van de Winkel, J.G.J., and Verbeek, J.S. 2002. FcgR1 (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection. Immunity. 16:391-402.

Anderson, C.A. and Mosser, D.M.. 2002. Cutting Edge: Biasing immune responses by directing antigen to macrophage Fcg receptors. J. Immunology. 168:3697-3701.

Anderson, C.A. and Mosser, D.M.. 2002. A novel macrophage phenotype: the Type II macrophage. J. Leukocyte Biology. 72:101-106.

Tietzel, I.T. and Mosser, D.M.. 2002.  The modulation of macrophage activation by tyrosine phosphorylation.  Frontiers in Bioscience.  7:1494-1502.

Anderson, C.F., Gerber, J.S., and Mosser, D.M.. 2002.  Modulatin macrophage fuction with IgG immune complexes. J. Endotoxin Research 8:477-481.

Mosser, D.M.. 2003.  Conceptual Perspective: The many faces of macrophage activation.  J. Leukocyte Biology 73:209-212.

Sunderkotter, C., Mosser, D.M.., Ridley, A., Sorg, C., and Roth, J. 2003. Molecular mechanisms of inflammation: how leukocytes come, see and seize.  European J Cell Biol. 82:379-83.

Anderson, C.A., Lucas, M., Gutierrez-Kobh, L., Field, A.E., and Mosser, D.M.. 2004. T cell biasing by activated dendritic cells. J. Immunology 173:955-961.

Darrah, P.A., Monaco, M.C., Jain, S., Hondalus, M.K., Golenbock, D.T. and Mosser, D.M.. 2004. Innate immune responses to Rohdococcus equi. J.Immunology, 173:1914-24.

Miles, S.A., Conrad, S.M., Alves, R.G., Jeronimo, S.M.B., and Mosser, D.M.. 2005. A role for immune complexes during infection with the intracellular pathogen, Leishmania spp.  J. Experimental Medicine. 201:747-754.

Goncalves, R., Vieira, E.R., Melo, M.N., Gollob, K.J., Mosser, D.M.., and Tafuri, W.L. 2005. A sensitive flow cytometric methodology for studying the binding of L. chagasi to canin peritoneal macrophages. BMC Infec. Diseases.  5:39-49.

Lucas, M, Zhang, X., Prasanna, V. and Mosser, D.M.. 2005.  ERK activation following macrophage FcgR ligation leads to chromatin modifications at the IL-10 locus. J. Immunol. 175:469-77.

Miles, S.A. and Mosser, D.M.. 2006.  Avoidance of innate immune mechanisms by the protozoan parasite, Leishmania spp. In Protozoans in Macrophages eds Denkers and Gazinelli, Landes Biosciences.

Zhang, X., Edwards, J.P., and Mosser, D.M.. 2006. Dynamic and transient remodelling of the macrophage IL-10 promoter during ranscription. J. Immunology. 177:1282-1288.

Edwards, J.P., Zhang, X., Frauwirth, K., and Mosser, D.M.. 2006. Biochemical and Functional Characterization of Three Activated Macrophage Populations. J. Leukocyte Biol. In Press.

Cao, SJ., Zhang, X., Edwards, J.P., and Mosser, D.M. 2006.  NF-kappaB1 (p50) homodimer differentially regulate pro- and anti-inflammatory cytokines in macrophages.  J. Biological Chemistry. In Press.

Previous Graduate Students (year of Ph.D. and present position)

Mary K. Hondalus, 1995, Research Assistant Professor, Harvard School Public Health
Dona C. Love, 1996, Staff Scientist, National Institutes of Health
Andrew Brittingham, 1998, Assistant Professor, Des Moines University, School of Osteopathic Medicine
Fayyaz Sutterwala (MD/PhD student), 1999, Resident, Yale Medical School
Margaret Mentink Kane, 2001, postdoctoral fellow, National Institutes of Health
Gang Chen, 2001, Informatics Programer, Scott Levie Co.
Jeffrey Gerber (MD/PhD student), 2001, Resident, Childrens Hospital of Pennsylvania
Patricia Darrah, 2001, postdoctoral fellow, National Institutes of Health
Charles Anderson, 2002, postdoctoral fellow, National Institutes of Health
Suzanne A. Miles, 2005
 

Current lab members

Xia Zhang, Ph.D., Research Assistant Professor
Shanjin Cao, Ph.D., Research Assistant Professor
Dalit Strauss-Ayali, Ph.D., Postdoctoral fellow
Sean Conrad, Graduate student
Ann E. Field, Graduate student
Justin P. Edwards, Graduate student
Ron Yahil, Graduate student
Ziyan Yang, Graduate student
Melba Munoz Roldan, Graduate Student
Sagie Wagage , Undergraduate Student
Omar Karin, Undergraduate Student