Selected Publications By Year

2010

J. L. Miller, K. Velmurugan, M. J. Cowan and V. Briken. The Type I NADH Dehydrogenase of Mycobacterium Tuberculosis Counters Phagosomal NOX2 Activity to Inhibit TNF-a-mediated Host Cell Apoptosis. PLOS Pathogens (2010) 6(4): e1000864. doi:10.1371/journal.ppat.1000864

G. Hettiarachchi, D. Nguyen, J. Wu, D. Lucas, D. Ma, L. Isaacs, V. Briken. Toxicology and Drug Delivery by Cucurbit[n]uril Type Molecular Containers. PLOS ONE (2010) 5(5):e10514

2009

Ildiko van Rhijn, David C. Young, Jenny Vasquez, Annemieke De Jong, Rahul Talekar, Joel T. Katz, Richard Riese, Ruth Ruprecht, Peter B. O’Connor, Catherine E. Costello, Steven A. Porcelli, Volker Briken, and D. Branch Moody. CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids. J.Exp. Med. 206(6): 1409-22 (2009)

2008

 Briken V.,  Living on the edge: inhibition of host cell apoptosis by Mycobacterium tuberculosis. Future Microbiol. 3 (4)

 Briken V., Molecular mechanisms of host-pathogen interactions and their potential for the discovery of new drug targets. Current Drug Targets 9 (2):150-57 (2008)

 Irwin, S.M., Goodyear, A., Keyser, A., Christensen, R., Troudt, J.M., Taylor, J.L.,

Bohsali, A., Briken V. and Izzo, A.A. Analysis of the immune response in the C57BL/6 mouse model induced by three Mycobacterium bovis BCG sub-strains with diverse regions of deletion. Clin. Vac. Immunol. (2008)

 2007

Velmurugan, K., B. Chen, J. Miller, S. Azogue, S. Gurses, T. Hsu, M. Glickman, W.R. Jacobs Jr, S.A. Porcelli, and V. Briken. Mycobacterium tuberculosis nuoG is a virulence gene that inhibits apoptosis of infected host cells. PLOS Pathogens 3 (7): e110 (2007)

Marbach-Ad, G., Briken, V., Frauwirth, K., Gao, L.,  Hutcheson, S.W., Joseph, S.W., Mosser, D., Parent, B, Shields, P., Song, W., Stein, D.C., Swanson, K., Thompson, K.V., Yuan, R., Smith, A.C. 2007. A Faculty Team Works to Create Content Linkages among Various Courses to Increase Meaningful Learning of Targeted Concepts of Microbiology. CBE Life Sci Educ 6 (2): 155-162 (2007)

2006

Cheng TY, Relloso M, Van Rhijn I, Young DC, Besra GS, Briken V, Zajonc DM, Wilson IA, Porcelli S, Moody DB. Role of lipid trimming and CD1 groove size in cellular antigen presentation. EMBO J. 25(13):2989-99 (2006)

2004

D. Dao, L. Kremer, Y. Guérardel, A. Molano, W.R. Jacobs Jr., S.A. Porcelli and V. Briken. Mycobacterium tuberculosis lipomannan induces apoptosis and IL-12 production of macrophages. Infection and Immunity 72 (4):2067-2074 (2004).

Matsunaga I, Bhatt A, Young DC, Cheng TY, Eyles SJ, Besra GS, Briken V, Porcelli SA, Costello CE, Jacobs WR Jr, Moody DB. Mycobacterium tuberculosis pks12 produces a novel polyketide presented by CD1c to T cells. J.Exp.Med. 200(12):1559-69 (2004).

Briken V, Porcelli SA, Besra GS and L. Kremer. Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response. Mol. Microbiology 53 (2):391-403 (2004).

2003

Guérardel Y, Maes E, Briken V, Chirat F, Leroy Y, Locht C, Strecker G, and Kremer L. Lipomannan and lipoarabinomannan from a clinical isolate of Mycobacterium kansasii: novel structural features and apoptosis-inducing properties. J.B.C. 278(38):36637-51. (2003).

2002

Briken V, Jackman RM, Doupta S, Kelly R, Hoening S and SA Porcelli. Intracellular trafficking pathway of newly synthesized CD1b molecules.  EMBO J. 21 (4): 825-834 (2002).

Lankar D, Vincent-Schneider H, Briken V,Yokozeki T, Raposo G  and C Bonnerot. Dynamics of Major Histocompatibility Complex Class II Compartments during B Cell Receptor–mediated Cell Activation. J. Exp. Med. 195 (4):461-472 (2002).

Moody DB, Briken V, Guy MR, Cheng TY, Geho D, Tykocinski M, Besra GS, and Porcelli SA.  Lipid length controls sorting of bacterial glycolipids into endosomal and nonendosomal antigen presentation pathways. Nature Immunol. 3 (5) 435-442 (2002).

2000

Briken V, Jackman RM, Watts G, Rogers RA and  SA Porcelli.  Human CD1 isoforms survey different intracellular compartments for the presentation of lipid antigens from Mycobacterium tuberculosis.  J. Exp. Med. 192:281-287 (2000).

Briken V, Moody DB, Porcelli SA.  Diversification of CD1 proteins: sampling the lipid content of different cellular compartments.  Sem. Immunol., 12:517-525 (2000).

1998

Briken V, Lankar D, and Bonnerot Ch. New evidence for two MHC class II restricted antigen presentation pathways by overexpression of a small G protein. J.Immunol 159:4653-4658 (1997).

Amigorena S, Lankar D, Briken V, Gapin L, Viguier M and  Bonnerot C. Type II and III receptors for IgG control the presentation of different T cell epitopes from single IgG-complexed antigens. J Exp. Med. 187:(4) 505-515 (1998).

Bonnerot Ch*, Briken V*, Brachet V., Lankar D., Cassard S., Jabri B., and S. Amigorena. Syk protein tyrosine kinase regulates Fc receptor g chain-mediated transport to lysosomes. EMBO J. 17 (16) 4606-4616 (1998). (*authors contributed equally)

Lankar D*, Briken V*, Adler K., Weiser P., Cassard S., Blank U., Viguier M. and Ch. Bonnerot Syk tyrosine kinase and BcR Ig-a subunit determine BcR-mediated MHC class II restricted antigen presentation. J. Exp. Med. 188: (5) 819-831 (1998). (*authors contributed equally)

1995

Briken V, Ruffner H, Schultz U, Schwarz A, Reis LF, Strehlow I, Decker T, and Staeheli P. Transcription factor IRF-1 is required for mouse GBP gene activation by interferon-gamma. Mol.Cell.Biol. 15, 975-982 (1995).