Regulation of VDAC and mitochondrial outer membrane permeability:

Holden, M.J., and Colombini, M. 1993. The outer mitochondrial membrane channel, VDAC, is modulated by a protein localized in the intermembrane space. Biochimica et Biophysica Acta, 1144:396-402.

Zizi, M., Forte, M., Blachly-Dyson, E. and Colombini, M. 1994. NADH regulates the gating of VDAC, the mitochondrial outer membrane channel. Journal of Biological Chemistry, 269:1614-1616.

Liu, M.Y., Torgrimson, A. and Colombini, M. 1994. Characterization and partial purification of the VDAC-channel-modulating protein from calf liver mitochondria. Biochimica et Biophysica Acta, 1185:203-212.

Lee, A., Zizi, M. and Colombini, M. 1994. -NADH decreases the permeability of the mitochondrial outer membrane to ADP by a factor of 6. Journal of Biological Chemistry, 269: 30974-30980.

Ahmadzadeh, M., Horng, A., and Colombini, M. 1996. The Control of Mitochondrial Respiration in Yeast: A Possible Role of the Outer Mitochondrial Membrane. Cell Biochem. Funct., 14: 201-208.

Lee, A., Xu, X., and Colombini, M. 1996. The role of pyridine dinucleotides in regulating the permeability of the mitochondrial outer membrane. Journal of Biological Chemistry, 271: 26724-26731.

Lee, A., and Colombini, M. 1997. An unique method for determining the permeability of the mitochondrial outer membrane. Methods in Cell Science, 19: 71-81.

Lee, A., Xu, X., Blachly-Dyson, E., Forte, M. and Colombini, M. 1997. The role of yeast VDAC genes on the permeability of the mitochondrial outer membrane. Journal of Membrane Biology, 161:173-181.

Xu, X., Forbes, J.G., and Colombini, M.  2001.  Actin modulates the gating of Neurospora crassa VDAC.  Journal of Membrane Biology, 180: 73-81.

Lai, J.C., Tan, W., Benimetskaya, L., Miller, P., Colombini, M., and Stein, C.A. 2006.  A pharmacologic target of G3139 in melanoma cells may be the mitochondrial VDAC. Proceedings of the National Academy of Sciences U.S.A., 103:7494-7499.  Full Text

Lai, J.C., Brown, B.D., Voskresenskiy, A.M., Vonhoff, S., Klussman, S., Tan, W., Colombini, M., Weeratna, R., Miller, P., Benimetskaya, L., and Stein, C.A. 2007. Comparison of D-G3139 and Its Enantiomer L-G3139 in Melanoma Cells Demonstrates Minimal  In Vitro but Dramatic In Vivo Chiral Dependency.  Molecular Therapy, 15: 270-280.

Tan, W., Lai, J.C., Miller. P., Stein, C.A., and Colombini, M. 2007. Phosphorothioate Oligonucleotides Reduce Mitochondrial Outer Membrane Permeability to ADP. American Journal of Physiology 292: C1388-C1397.  Full Text

Tan W., Loke Y.H., Stein C.A., Miller P. and Colombini M. 2007. Phosphorothioate Oligonucleotides Block the VDAC Channel. Biophysical Journal 93: 1184-1191. Full Text

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